Biological Prognostic Parameters in Gastric Carcinomas
T. Potecă, A. Potecă, M. Sajin, M. ComănescuOriginal article, no. 3, 2014
Gastric cancer is the second leading cause of cancer mortalityworldwide. (1) Gastric carcinogenesis involves a variety offactors including diet, habitual factors as well as environmentalfactors. (2,3) This study aimed to correlate clinicopathologicalparameters of the cases studied and PCNA and p53 expressionusing immunohistochemistry. The study group included a totalof 32 patients that underwent gastrectomy for gastric cancer.The study parameters were represented by epidemiologicalaspects (age, sex), clinical characteristics (signs and symptoms),histopathological findings (pTNM staging and degree ofdifferentiation, histological classification, lymph nodes statusand presence of vascular invasion) and survival, and immunohistochemicalanalysis (p53 and PCNA expression) of the studygroup. Histopathological study showed that most of the cases(26 cases) were of the intestinal type and 6 cases of the diffusetype. Immunohistochemical analysis of p53 protein expressionshowed an average of 20.75% positive cells, while PCNAexpression showed an average of 47.3%. In terms of survivalthere were 6 cases of death at intervals ranged from 2-189 days,5 cases had subsequent presentations over 12 months, while 8patients were lost to follow-up. At the time of surgery, 6 patientshad distant metastases, while 6 more developed them in aperiod of 2-12 months after surgery. Identification ofbiomolecules that highlight potentially aggressive tumors may help modulate the therapeutic approach after surgicalresection.
