Interleukin 6 and Lipopolysaccharide Binding Protein - Markers of Inflammation in Acute Appendicitis
C. Brănescu, D. Serban, A.M. Dascălu, S.M. Oprescu, C. SavlovschiOriginal article, no. 2, 2013
The rate of incidence of acute appendicitis is 12% in the case
of male patients and 25% in case of women, which represents
about 7% of the world population. The appendectomy rate has
remained constant (i.e. 10 out of 10,000 patients per year).
Appendicitis most often occurs in patients aged between 11-40
years, on the threshold between the third and fourth decades,
the average age being 31.3 years. Since the first appendectomy
performed by Claudius Amyand (1681/6 – 1740), on December,
6th, 1735 to our days, i.e., 270 years later, time has confirmed
the efficiency of both the therapy method and the surgical
solution. The surgical cure in case of acute appendicitis has
proved to be acceptable within the most widely practised
techniques in general surgery. The variety of clinical forms has reached all age ranges, which in its turn has resulted in a large
number of semiotic signs. In the case of acute appendicitis,
interdisciplinarity has allowed the transfer of concept and
methodology transfer among many areas of expertise, aimed at
a better, minute understanding of the inflammatory event
itself. Acute appendicitis illustrates inflammation development
at digestive level and provides for a diagnostic and paraclinical
exploration which continually upgrades. The recent inclusion
in the studies of the Lipopolysaccharide binding protein (LBP)-
type inflammation markers has laid the foundation of the
latter’s documented presence in the case of acute appendicitisrelated
inflammation. Proof of the correlation between the
histopathological, clinical and evolutive forms can be
found by identifying and quantifying these inflammation
markers. The importance of studying inflammation markers
allows us to conduct studies going beyond the prognosis of the
various stages in which these markers were identified. The
present article shows the results of a 1-year monitoring of
the inflammation markers’ values for Interleukin-6 and
Lipopolysaccharide binding protein (LBP)-types, both pre-op
and 3-days post-op in the case of patients diagnosed with acute
appendicitis in the Surgery Clinic IV of the Emergency
University Hospital - Bucharest.
The data collected have allowed us to correlate them with
the selected parameters, and to draw the conclusions
presented in this article.